The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
Oct. 26, 2008
David O. Bates, Bishopston Bristol, GB;
Steven J. Harper, Tintern Gwent, GB;
Miriam Y. Mengelus, Holon, IL;
Menachem Ze'evi, Ramat Gan, IL;
David O. Bates, Bishopston Bristol, GB;
Steven J. Harper, Tintern Gwent, GB;
Miriam Y. Mengelus, Holon, IL;
Menachem Ze'evi, Ramat Gan, IL;
Philogene, Inc., Summit, NJ (US);
University of Bristol, Bristol, GB;
Abstract
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.