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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8591943 B1

PDFFull Text
Date of Patent:
Nov. 26, 2013

Filed:

Apr. 08, 2010

Pyrazolo[1,5-a]pyrimidine derivatives as mtor inhibitors

Applicants:

Yongqi Deng, Newton, MA (US);

Binyuan Sun, Chestnut Hill, MA (US);

Hongbo Zeng, Westford, MA (US);

Matthew Richards, Somerville, MA (US);

Gerald W. Shipps, Jr., Stoneham, MA (US);

Cliff C. Cheng, Cambridge, MA (US);

Yinyan Zhao, Rockville, MD (US);

Andrew Mcriner, Melrose, MA (US);

Zhaoyang Meng, Lansdale, PA (US);

Yang Nan, Lansdale, PA (US);

Mehul F. Patel, Willow Grove, PA (US);

Iwona E. Wrona, Sharon, MA (US);

Panduranga Adulla Reddy, Walpole, MA (US);

Brian M. Eklov, Kalamazoo, MI (US);

Shuyi Tang, Belmont, MA (US);

Duan Liu, Arlington, MA (US);

Amit K. Mandal, Shrewsbury, MA (US);

Lianyun Zhao, Blue Bell, PA (US);

M. Arshad Siddiqui, Newton, MA (US);

Inventors:

Yongqi Deng, Newton, MA (US);

Binyuan Sun, Chestnut Hill, MA (US);

Hongbo Zeng, Westford, MA (US);

Matthew Richards, Somerville, MA (US);

Gerald W. Shipps, Jr., Stoneham, MA (US);

Cliff C. Cheng, Cambridge, MA (US);

Yinyan Zhao, Rockville, MD (US);

Andrew McRiner, Melrose, MA (US);

Zhaoyang Meng, Lansdale, PA (US);

Yang Nan, Lansdale, PA (US);

Mehul F. Patel, Willow Grove, PA (US);

Iwona E. Wrona, Sharon, MA (US);

Panduranga Adulla Reddy, Walpole, MA (US);

Brian M. Eklov, Kalamazoo, MI (US);

Shuyi Tang, Belmont, MA (US);

Duan Liu, Arlington, MA (US);

Amit K. Mandal, Shrewsbury, MA (US);

Lianyun Zhao, Blue Bell, PA (US);

M. Arshad Siddiqui, Newton, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Li Su

David A. Muthard

Primary Examiner:

Ernst Arnold

Assistant Examiner:

Jianfeng Song

Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 39/395 (2006.01); A61K 31/554 (2006.01); A61K 31/541 (2006.01); A61K 31/5377 (2006.01); A61K 38/50 (2006.01); A61K 31/553 (2006.01); A61K 33/24 (2006.01); A61K 31/704 (2006.01); A61K 31/551 (2006.01); A61K 31/538 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

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