The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
Mar. 10, 2008
William R. Jacobs, Jr., Pelham, NY (US);
Kari Sweeney, Stamford, CT (US);
Dee Dao, Bronx, NY (US);
Steven A. Porcelli, Bronx, NY (US);
John Chan, Hastings-on-Hudson, NY (US);
Tsungda Hsu, New York, NY (US);
William R. Jacobs, Jr., Pelham, NY (US);
Kari Sweeney, Stamford, CT (US);
Dee Dao, Bronx, NY (US);
Steven A. Porcelli, Bronx, NY (US);
John Chan, Hastings-on-Hudson, NY (US);
Tsungda Hsu, New York, NY (US);
Albert Einstein College of Medicine of Yeshiva University, Bronx, NY (US);
Abstract
Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.