The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 26, 2013

Filed:

Jul. 07, 2011
Applicants:

Yoshio Hirabayashi, Wako, JP;

Hiroyuki Kamiguchi, Wako, JP;

Kunihiro Ohta, Wako, JP;

Akiho Nakamura, Wako, JP;

Inventors:

Yoshio Hirabayashi, Wako, JP;

Hiroyuki Kamiguchi, Wako, JP;

Kunihiro Ohta, Wako, JP;

Akiho Nakamura, Wako, JP;

Assignee:

Riken, Saitama, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 31/7028 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
Abstract

In order to identify a factor demonstrating a repellent effect on axon extension of a neuron, lysophosphatidylglucoside (LPG) has been found to have an activity as a chemorepellent effect on axon guidance of a DRG sensory neuron specific to a neuron expressing TrkA, an NGF receptor. In addition, it has been found out that suppressing the function of LPG makes it possible to suppress a repellent effect of LPG on axon extension of a neuron expressing TrkA. A molecule capable of suppressing the function of LPG can be a composition promoting repairing of a neural circuit in neuronal damages and the like.


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