The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
Jul. 18, 2012
Lapo Alinari, Dublin, OH (US);
Robert A. Baiocchi, Dublin, OH (US);
Natarajan Muthusamy, Galloway, OH (US);
Hans J. Hansen, Picayune, MS (US);
David M. Goldenberg, Mendham, NJ (US);
Lapo Alinari, Dublin, OH (US);
Robert A. Baiocchi, Dublin, OH (US);
Natarajan Muthusamy, Galloway, OH (US);
Hans J. Hansen, Picayune, MS (US);
David M. Goldenberg, Mendham, NJ (US);
The Ohio State University, Columbus, OH (US);
Immunomedics, Inc., Morris Plains, NJ (US);
Abstract
Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.