The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
Apr. 05, 2010
Applicants:
James Turkson, Orlando, FL (US);
Patrick Gunning, Mississauga, CA;
Inventors:
James Turkson, Orlando, FL (US);
Patrick Gunning, Mississauga, CA;
Assignees:
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
Governing Council of the University of Toronto, Ontario, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/60 (2006.01); C07C 315/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.