The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
Jun. 25, 2010
Samuel Davis, New York, NY (US);
Eric Smith, New York, NY (US);
Douglas Macdonald, New York, NY (US);
Kara Louise Olson, White Plains, NY (US);
Samuel Davis, New York, NY (US);
Eric Smith, New York, NY (US);
Douglas MacDonald, New York, NY (US);
Kara Louise Olson, White Plains, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.