The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
Apr. 28, 2003
Koenraad Mertens, Leiden, NL;
Arend N. Bovenschen, Utrecht, NL;
Jan Voorberg, Wormer, NL;
Manfred Rieger, Gaenserndorf, AT;
Friedrich Scheiflinger, Vienna, AT;
Koenraad Mertens, Leiden, NL;
Arend N. Bovenschen, Utrecht, NL;
Jan Voorberg, Wormer, NL;
Manfred Rieger, Gaenserndorf, AT;
Friedrich Scheiflinger, Vienna, AT;
Stichting Sanquin Bloedvoorziening, Amsterdam, NL;
Abstract
The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor VIII half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.