The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
Sep. 06, 2011
Masayuki Tsuchiya, Shizuoka-ken, JP;
Toshihiko Ohtomo, Shizuoka-ken, JP;
Naohiro Yabuta, Ibaraki, JP;
Hiroyuki Tsunoda, Ibaraki, JP;
Tetsuro Orita, Ibaraki, JP;
Masayuki Tsuchiya, Shizuoka-ken, JP;
Toshihiko Ohtomo, Shizuoka-ken, JP;
Naohiro Yabuta, Ibaraki, JP;
Hiroyuki Tsunoda, Ibaraki, JP;
Tetsuro Orita, Ibaraki, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.