The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2013
Filed:
Jun. 23, 2011
Reto Schoch, Speicherschwendi, CH;
Reto Schoch, Speicherschwendi, CH;
Swissfluidics AG, Gais, CH;
Abstract
An isotachophoresis method for preconcentrating and isolating a plurality n of charged analytes (A, with i=1 to n) contained in a sample is disclosed, wherein each one of the analytes Ahas an effective electrophoretic mobility μobeying the fully ordered relationship μ>μ>etc.>μ, comprising the step of preparing a mixture of said sample and a number n−1 of spacer compounds (S, with k=1 to n−1) wherein each one of said spacer compounds (S) has an effective electrophoretic mobility μobeying the fully ordered relationship μ>μ>μ. An axial electric field is applied along the longitudinal axis of a separation channel, thereby causing a preconcentration and separation of the analytes and spacers forming respective focused spacer zones and focused analyte zones that flow along the longitudinal axis. Each one of the spacer compounds (S) has an initial concentration (c) selected in such manner as to substantially correspond, at its preconcentrated concentration (c) in the respective focused spacer zone, to a volume of the main separation channel enclosed between an associated pair of adjacent extraction channels (E) and (E). Through this spatial displacement of analytes Aby spacers S, the analytes can be selectively extracted into the extraction channels E.