The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Jul. 11, 2011
Amedeo Leonardi, Milan, IT;
Gianni Motta, Barlassina, IT;
Carlo Riva, Varese, IT;
Luciano Guarneri, Garbagnate Milanese, IT;
Davide Graziani, Milan, IT;
Carlo DE Toma, Milan, IT;
Katia Dimitrova Karamfilova, Sesto San Giovanni, IT;
Amedeo Leonardi, Milan, IT;
Gianni Motta, Barlassina, IT;
Carlo Riva, Varese, IT;
Luciano Guarneri, Garbagnate Milanese, IT;
Davide Graziani, Milan, IT;
Carlo De Toma, Milan, IT;
Katia Dimitrova Karamfilova, Sesto San Giovanni, IT;
Recordati Ireland Ltd., Milan, IT;
Abstract
The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed.