The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Jul. 22, 2009
Robert M Jones, San Diego, CA (US);
Daniel J Buzard, San Diego, CA (US);
Sangdon Han, San Diego, CA (US);
Sun Hee Kim, San Diego, CA (US);
Juerg Lehmann, San Diego, CA (US);
Brett Ullman, San Diego, CA (US);
Jeanne V Moody, San Diego, CA (US);
Xiuwen Zhu, San Diego, CA (US);
Scott Stirn, San Diego, CA (US);
Robert M Jones, San Diego, CA (US);
Daniel J Buzard, San Diego, CA (US);
Sangdon Han, San Diego, CA (US);
Sun Hee Kim, San Diego, CA (US);
Juerg Lehmann, San Diego, CA (US);
Brett Ullman, San Diego, CA (US);
Jeanne V Moody, San Diego, CA (US);
Xiuwen Zhu, San Diego, CA (US);
Scott Stirn, San Diego, CA (US);
Arena Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia): and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.