The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Jul. 22, 2010
Matteo Zanda, Gandino, IT;
Monica Sani, Noviglio, IT;
Paolo Lazzari, Pula, IT;
Kemtech S.r.L., Cagliari, IT;
Abstract
Tubulysine compounds of formula (A) having a high cytotoxicity wherein:B is selected from CH, CH—CHor CH—CH—CH,D is an aromatic linker,Xis alkyl or alkenyl,Xis selected from the X, substituted or non substituted, selected from: aryl, heteroaryl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, or heteroarylalkyl,X: alkylene-O-alkyl, wherein alkylene is C-C,X: CH—O-alkyl,Xis selected from H, or together with Xforms the group ═O,Xis selected from H, halogen, OH, SH, alkyl, alkenyl, (OR)—OR, OC(O)R, NRR, or together with Xforms the group ═O,Ris an alkylene,n is zero or an integer from 1 to 10,Rand R, equal to or different from each other, have the following meanings: