The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Apr. 26, 2010
Stefan Hell, Goettingen, DE;
Vladimir N. Belov, Goettingen, DE;
Kirill Kolmakov, St. Petersburg, RU;
Volker Westphal, Hannover, DE;
Marcel Lauterbach, Goettingen, DE;
Stefan Jakobs, Goettingen, DE;
Christian Wurm, Goettingen, DE;
Christian Eggeling, Goettingen, DE;
Christian Ringemann, Goettingen, DE;
Stefan Hell, Goettingen, DE;
Vladimir N. Belov, Goettingen, DE;
Kirill Kolmakov, St. Petersburg, RU;
Volker Westphal, Hannover, DE;
Marcel Lauterbach, Goettingen, DE;
Stefan Jakobs, Goettingen, DE;
Christian Wurm, Goettingen, DE;
Christian Eggeling, Goettingen, DE;
Christian Ringemann, Goettingen, DE;
Abstract
The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues are useful as molecular mass distribution tags in mass spectroscopic applications, wherein R=an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group; R=H, an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group, or an unsubstituted or substituted aryl group or heteroaryl group, or any combination of such groups; X=CH, C═O, C═NOR, C═NNRNR, CH(OR), O, S, SO, SO, or any other derivatives of these groups, with Ra and Rb independently being H or an organic residue, in particular an unsubstituted or substituted (cyclo)alkyl group or heterocycloalkyl group, an unsubstituted or substituted aryl group or heteroaryl group; Z=a negatively charged group with 1, 2, 3, 4 or 5 charges per anion.