The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Oct. 08, 2010
Wenyong Chen, Temple City, CA (US);
Ravi Bhatia, Duarte, CA (US);
Leila Su, Diamond Bar, CA (US);
Yate-ching Yuan, Arcadia, CA (US);
WenYong Chen, Temple City, CA (US);
Ravi Bhatia, Duarte, CA (US);
Leila Su, Diamond Bar, CA (US);
Yate-Ching Yuan, Arcadia, CA (US);
City of Hope, Duarte, CA (US);
Abstract
A method of generating a chronic myelogenic leukemia (CML) acquired chemoresistant culture model is provided. Such a method may comprise providing a naïve blast crisis CML cell line; administering/contacting the cell line with a mutation-inducing dose of imatinib; maintaining a culture of the treated cell line for a period of time until the treated cell line relapses and repopulates the culture; and determining the repopulated cell culture is a CML acquired chemoresistant cell line by detecting a BCR-ABL mutation, wherein the acquired chemoresistance is achieved by a BCR-ABL mutation.