The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Sep. 07, 2010
Applicants:
Haoyun an, Carlsbad, CA (US);
Kanda Ramasamy, Aliso Viejo, CA (US);
Stephanie Shaw, Rowland Heights, CA (US);
Inventors:
Haoyun An, Carlsbad, CA (US);
Kanda Ramasamy, Aliso Viejo, CA (US);
Stephanie Shaw, Rowland Heights, CA (US);
Assignee:
Valeant Pharmaceuticals North America, Bridgewater, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/167 (2006.01); C07H 19/173 (2006.01);
U.S. Cl.
CPC ...
Abstract
An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.