Pyrolinone derivative and pharmaceutical composition comprising the same

Abstract

The present invention provides a novel P2Xand/or P2X/receptor antagonist. A compound represented by the formula (I): wherein Zis optionally protected hydroxy, etc.; Zis —C(═O)—, etc.; Zand Zare taken together ═O or ═S; t is an integer of 0 to 4; Rand Rare each independently, hydrogen or substituted or unsubstituted lower alkyl, etc.; m and n are each independently an integer of 0 to 2; k is an integer of 0 or 1; Ring A is an aromatic carbocyclic ring or a heterocyclic ring, etc.; B is aromatic carbocyclic ring-diyl or heterocyclic ring-diyl, etc.; Rand Rare each independently halogen, hydroxy, substituted or unsubstituted lower alkyl, etc.; Ris substituted or unsubstituted alkyl, etc.; Ris substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; or its pharmaceutically acceptable salt, or a solvate thereof is provided.