Non-steroidal compounds useful as glucocorticoid receptor modulators

Abstract

This invention relates to novel amino acid derivatives of formula (I) wherein the R groups have the following meanings: —Ris —H or —(1-4C)alkyl; —Ris —C(O)Ror —S(O)R; —Ris —H, —(1-4C)alkyl or —OR; —Ris —H, —(1-4C)alkyl or —OR; —Ris —H or —C(R)NOR; —Ris —H, -halogen, -cyano; —(1-6C)alkyl, —(2-6C)alkenyl or —(2-6C)alkynyl, all optionally substituted with -amino, -hydroxyl or -halogen; —Ris —H, -cyano, -halogen, -nitro; —(1-6C)alkyl, —(2-6C)alkenyl, —(2-6C)alkynyl or —O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen; -(hetero)aryl, optionally substituted with -cyano, -halogen, —(1-4C)alkyl, —(1-4C)alkoxy, —(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl; —C(R)NOR; —C(O)N(R); —C(O)R18, —C(O)OR, —NHC(O)R, or —NHS(O)R; —Ris —H, -halogen, -cyano, or —(1-4C)alkyl, optionally substituted with -halogen; —Ris —H or —(1-4C)alkyl; —Ris —H; —Ris —H, -cyano or —(1-4C)alkyl; —Ris —H, —(1-4C)alkyl, -halogen or -formyl; —Ris —H, -halogen, -cyano, —(1-4C)alkyl or -(hetero)aryl; or a pharmaceutically acceptable salt thereof. The compounds of this invention are highly specific for the glucocorticoid receptor and may be used for treating inflammatory diseases.