The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Dec. 10, 2009
Pieter Smid, Weesp, NL;
Michael Mlinaric, Hannover, DE;
Konrad F. Koehler, Huddinge, SE;
Sara Nuñez Garcia, Weesp, NL;
Elmar Wegener, Hannover, DE;
Josephus H. M. Lange, Weesp, NL;
Pieter Smid, Weesp, NL;
Michael Mlinaric, Hannover, DE;
Konrad F. Koehler, Huddinge, SE;
Sara Nuñez Garcia, Weesp, NL;
Elmar Wegener, Hannover, DE;
Josephus H. M. Lange, Weesp, NL;
Abbott Healthcare Products B.V., Weesp, NL;
Abstract
This invention concerns spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers, pharmaceutical compositions containing these compounds, methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in the treatment of diabetes, psoriasis, obesity, transplant rejection and inflammatory neuropathies, including T-cell mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The compounds have formula (1): wherein R, R, (R), and (R)have the meanings given in the specification.