The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Dec. 12, 2008
Nikolai Kouznetsov, Jarfalla, SE;
Lisa Charlotta Bandholtz, Stockholm, SE;
Alexander Gielen, Bandhagen, SE;
Oliver Von Stein, Upplands Vasby, SE;
Petra Von Stein, Upplands Vasby, SE;
Nikolai Kouznetsov, Jarfalla, SE;
Lisa Charlotta Bandholtz, Stockholm, SE;
Alexander Gielen, Bandhagen, SE;
Oliver Von Stein, Upplands Vasby, SE;
Petra Von Stein, Upplands Vasby, SE;
Index Pharmaceuticals AB, Stockholm, SE;
Abstract
The invention concerns an in vitro method for selecting the therapy for a steroid resistant patient, wherein the method comprises isolating cells from a sample taken from said patient; cultivating said isolated cells in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof; determining an expression level of at least one marker gene in said isolated cells; and comparing said expression level of said at least one marker gene to a value obtained from the cultivation of cells from a healthy person in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof, or to a normalized value obtained from a healthy population. Examples of marker genes are CD163, Tsp1, IL1-R2, TLR2, TLR4, MKP-1 and TXK.