The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Feb. 03, 2010
Mazhar Adli, Malden, MA (US);
Bradley E. Bernstein, Cambridge, MA (US);
Tarjei S. Mikkelsen, Cambridge, MA (US);
Mazhar Adli, Malden, MA (US);
Bradley E. Bernstein, Cambridge, MA (US);
Tarjei S. Mikkelsen, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The General Hospitall Corporation, Boston, MA (US);
Abstract
Improvements in chromatin immunoprecipitation-high throughput sequencing techniques has allowed the creation of chromatin maps from limited biological sample sizes that cannot be evaluated using conventional chromatin immunoprecipitation-sequencing protocols. For example, a modified universal primer is utilized that incorporates restriction enzymes into chromatin immunoprecipitation fragments before amplification. The improved method allows the sample sizes to be several orders of magnitude less than that required for standard ChIP-Seq techniques.