The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Sep. 13, 2012
Erich Hoffmann, Galveston, TX (US);
Aleksandr S. Lipatov, Atlanta, GA (US);
Richard J. Webby, Memphis, TN (US);
Elena A. Govorkova, Cordova, TN (US);
Robert G. Webster, Memphis, TN (US);
Erich Hoffmann, Galveston, TX (US);
Aleksandr S. Lipatov, Atlanta, GA (US);
Richard J. Webby, Memphis, TN (US);
Elena A. Govorkova, Cordova, TN (US);
Robert G. Webster, Memphis, TN (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
Abstract
The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.