The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2013
Filed:
Oct. 04, 2011
José M. Carballido Herrera, Allschwil, CH;
Stefan Hartle, Jesenwang, DE;
Christoph Heusser, Oberwil, CH;
Ingo Klagge, Neuried, DE;
Andrea Polzer, München, DE;
Christoph Schwaerzler, St Louis, FR;
Gabriela Wochnik-veltrup, Eching a.A, DE;
José M. Carballido Herrera, Allschwil, CH;
Stefan Hartle, Jesenwang, DE;
Christoph Heusser, Oberwil, CH;
Ingo Klagge, Neuried, DE;
Andrea Polzer, München, DE;
Christoph Schwaerzler, St Louis, FR;
Gabriela Wochnik-Veltrup, Eching a.A, DE;
Novartis AG, Basel, CH;
Abstract
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/1L18 induced IFNγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.