The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Nov. 15, 2007
Colin C. Hill, Somerville, MA (US);
Bruce W. Church, Lawrence, MA (US);
Paul D. Mcdonagh, Winchester, MA (US);
Iya G. Khalil, Boston, MA (US);
Thomas A. Neyarapally, Boston, MA (US);
Zachary W. Pitluk, New Haven, CT (US);
Colin C. Hill, Somerville, MA (US);
Bruce W. Church, Lawrence, MA (US);
Paul D. McDonagh, Winchester, MA (US);
Iya G. Khalil, Boston, MA (US);
Thomas A. Neyarapally, Boston, MA (US);
Zachary W. Pitluk, New Haven, CT (US);
Gene Network Sciences, Inc., Cambridge, MA (US);
Abstract
The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity.