The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Dec. 18, 2009
Eva Againe Csongor, Pomaz, HU;
Laszlo Czibula, Budapest, HU;
Ferenc Sebok, Mezokovacshaza, HU;
Balint Juhasz, Torokbalint, HU;
Janos Galambos, Budapest, HU;
Katalin Nogradi, Budapest, HU;
Eva Againe Csongor, Pomaz, HU;
Laszlo Czibula, Budapest, HU;
Ferenc Sebok, Mezokovacshaza, HU;
Balint Juhasz, Torokbalint, HU;
Janos Galambos, Budapest, HU;
Katalin Nogradi, Budapest, HU;
Richter Gedeon Nyrt., Budapest, HU;
Abstract
The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of general formula (I) by reacting the compound of formula (III) with a carbamoylchloride of general formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100° C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.