The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Dec. 19, 2008
Judith M. Gottwein, Frederiksberg C, DK;
Troels Kasper Hoyer Scheel, Kobenhavn NV, DK;
Tanja Bertelsen Jensen, Frederiksberg C, DK;
Jens Bukh, Praesto, DK;
Judith M. Gottwein, Frederiksberg C, DK;
Troels Kasper Hoyer Scheel, Kobenhavn NV, DK;
Tanja Bertelsen Jensen, Frederiksberg C, DK;
Jens Bukh, Praesto, DK;
Hvidovre Hospital, Hvidovre, DK;
Abstract
The present inventors developed hepatitis C virus 6a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 6a reference strain HK6a. Sequence analysis of recovered 6a/2a recombinants from 2 transfection experiments and subsequent reverse genetic studies revealed adaptive mutations in E1 and E2. Conclusion: The developed 6a/2a viruses provide a robust in vitro tool for research in HCV genotype 6, including vaccine studies and functional analysis.