The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Apr. 23, 2010
Yan-yeung Luk, Jamesville, NY (US);
Dawei Cui, Syracuse, NY (US);
Debjyoti Bandyopadhyay, Syracuse, NY (US);
Deepali Prashar, Syracuse, NY (US);
Preeti Sejwal, Cranbury, NJ (US);
Karen Simon, Fayetteville, NY (US);
Yan-Yeung Luk, Jamesville, NY (US);
DaWei Cui, Syracuse, NY (US);
Debjyoti Bandyopadhyay, Syracuse, NY (US);
Deepali Prashar, Syracuse, NY (US);
Preeti Sejwal, Cranbury, NJ (US);
Karen Simon, Fayetteville, NY (US);
Syracuse University, Syracuse, NY (US);
Abstract
A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.