The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Jun. 16, 2010
Paolo Morazzoni, Milan, IT;
Antonella Riva, Milan, IT;
Cesare Ponzone, Milan, IT;
Davide Berlanda, Milan, IT;
Marcello Duranti, Milan, IT;
Alessandro Consonni, Milan, IT;
Paolo Morazzoni, Milan, IT;
Antonella Riva, Milan, IT;
Cesare Ponzone, Milan, IT;
Davide Berlanda, Milan, IT;
Marcello Duranti, Milan, IT;
Alessandro Consonni, Milan, IT;
Indena S.p.A., Milan, IT;
Abstract
A truncated form of α' chain (eα′), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha′ subunit. The eα′ polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.