The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 29, 2013

Filed:

Jun. 03, 2011
Applicants:

Thomas H. Graham, Scotch Plains, NJ (US);

Wensheng Liu, Edison, NJ (US);

Iyassu K. Sebhat, Jersey City, NJ (US);

Dong-ming Shen, Edison, NJ (US);

Zhi-cai Shi, Monmouth Junction, NJ (US);

Inventors:

Thomas H. Graham, Scotch Plains, NJ (US);

Wensheng Liu, Edison, NJ (US);

Iyassu K. Sebhat, Jersey City, NJ (US);

Dong-Ming Shen, Edison, NJ (US);

Zhi-Cai Shi, Monmouth Junction, NJ (US);

Assignee:

Merck Sharp & Dohme Corp, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/454 (2006.01); C07D 413/14 (2006.01); C07D 401/02 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.


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