The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Jun. 11, 2012
Jean-philippe Annereau, Toulouse, FR;
Jean-marc Barret, Castres, FR;
Yves Guminski, Lagarrigue, FR;
Thierry Imbert, Viviers les Montagnes, FR;
Jean-Philippe Annereau, Toulouse, FR;
Jean-Marc Barret, Castres, FR;
Yves Guminski, Lagarrigue, FR;
Thierry Imbert, Viviers les Montagnes, FR;
Pierre Fabre Medicament, Boulogne-Billancourt, FR;
Abstract
The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumors in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: Ris one or more NOgroups in position 4 or 6, or a SOPh, SONMe, SONHor SOH group; Ris hydrogen, Calkyl, benzyl, a perfluoroalkyl group; the values of a, b, c range from 2 to 5 independently from each other and represent alkylene chains separating the amino groups, and the values of d and e can independently be 0 or 1.