The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
May. 21, 2009
David M. Donovan, Baltimore, MD (US);
Stephen C. Becker, Baltimore, MD (US);
David M. Donovan, Baltimore, MD (US);
Stephen C. Becker, Baltimore, MD (US);
The United States of America, as represented by the Secretary of Agriculture, Washington, DC (US);
Abstract
Multi-drug resistant superbugs are a persistent problem in modern health care. LysK is a staphylococcal bacteriophage endolysin from the phage K. It is a peptidoglycan hydrolase enzyme that can lyse many staphylococcal strains and thus is a potent antimicrobial against, including MRSA. Lysostaphin is a bacteriocin secreted byto kill, and has been shown to also be a potent antimicrobial for many antibiotic resistant strains of. This study describes optimal reaction conditions for the recombinant His-tagged LysK protein, compares its MIC and antimicrobial activity to lysostaphin and demonstrates synergy when the two are used in combination against the MRSA USA300.