The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 2013
Filed:
Jan. 23, 2009
Paul Cunnien, Cary, NC (US);
Joydeep Ganguly, Boston, MA (US);
Basav Ghosh, Apex, NC (US);
Asif Ladiwala, San Diego, CA (US);
Robert Song, Scituate, MA (US);
Jorg Thommes, San Diego, CA (US);
Paul Cunnien, Cary, NC (US);
Joydeep Ganguly, Boston, MA (US);
Basav Ghosh, Apex, NC (US);
Asif Ladiwala, San Diego, CA (US);
Robert Song, Scituate, MA (US);
Jorg Thommes, San Diego, CA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The present invention provides automated systems and methods for monitoring column performance in process chromatography, and applications thereof. In an embodiment, column performance is monitored by generating a plurality of process values such as, for example, conductivity values or pH values with a detector during a chromatography step transition between a first mobile phase liquid and a second mobile phase liquid. The process values are transformed to form transformed process values in which noise present in the process values is suppressed. Column performance parameters are calculated based on the transformed process values and displayed during movement of the second mobile phase liquid through the chromatography column. The displayed performance parameters enable an operator to make a determination, for example, regarding the quality of the chromatography column packing and whether to continue the chromatography process or stop the chromatography process until the chromatography column can be repacked or replaced.