Methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography and spectral domain phase microscopy

Abstract

In accordance with this disclosure, methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography are provided. Synthetic wavelength phase unwrapping can be applied to OCT data and can correctly resolve sample motions that are larger than λ/2. A method for phase unwrapping of an OCT signal can include acquiring raw OCT signal data, interpolating and processing the OCT signal data to obtain a DC spectrum, comparing the raw OCT signal data to the DC spectrum to generate an interference signal, applying Gaussian windows to the interference signal to generate a two separate signals, extracting phase information from the two signals, and comparing the phase information of the two signals to produce unwrapped phase data. A value of 2π can be added to the phase data if the difference between the phase information of the two signals is less than zero.