The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Jul. 07, 2010
Sambhu Prasad Sarma Mallela, Hyderabad, IN;
Sukumar Nandi, Hyderabad, IN;
Balanarasimha Reddy Gona, Hyderabad, IN;
Naresh Akkina, Hyderabad, IN;
Rani Ananta, Hyderabad, IN;
Islam Aminul, Hyderabad, IN;
Sivakumaran Meenakshisunderam, Hyderabad, IN;
Sambhu Prasad Sarma Mallela, Hyderabad, IN;
Sukumar Nandi, Hyderabad, IN;
Balanarasimha Reddy Gona, Hyderabad, IN;
Naresh Akkina, Hyderabad, IN;
Rani Ananta, Hyderabad, IN;
Islam Aminul, Hyderabad, IN;
Sivakumaran Meenakshisunderam, Hyderabad, IN;
Aurobindo Pharma Ltd., Hyderabad, IN;
Abstract
The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5α-androst-1-en-3-one-17β-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO)O in presence of base to produce an intermediate compound of Formula (XIII), wherein R represents Calkyl, Chalo alkyl, Caryl, halo aryl; (ii) condensing compound of Formula (XIII) with 2,5-bis(trifluoromethyl)aniline (III), Formula (III) in the presence or absence of a base to produce Dutasteride (I).