The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
May. 30, 2012
Hearan Suh, Seoul, KR;
Sang Kyu Nam, Seoul, KR;
Jong Sun Lee, Yongin-si, KR;
Seung Ki Kim, Suwon-si, KR;
Hearan Suh, Seoul, KR;
Sang Kyu Nam, Seoul, KR;
Jong Sun Lee, Yongin-si, KR;
Seung Ki Kim, Suwon-si, KR;
BCWorld Pharm. Co., Ltd., Yeoju-Gun, Kyunggi-Do, KR;
Abstract
The present invention relates to a novel method for preparing an imatinib base, and more particularly to a method for preparing an imatinib base, which comprises reacting 4-(4-methyl-piperazinomethyl)-benzoic acid with a 2,2'-dibenzothiazolyl disulfide derivative in the presence of a phosphine derivative to prepare a novel thioester compound and preparing an imatinib base using the thioester compound as a reaction intermediate. In addition, the invention provides a novel thioester compound, which is used in the preparation of imatinib base, and a preparation method thereof. Ultimately, the invention provides a method of preparing the imatinib base in an economic manner and in high yield and purity and is expected to be used in the commercial production of large amounts of the imatinib base.