The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 2013

Filed:

Oct. 04, 2012
Applicant:

Eisai R&d Management Co., Ltd., Tokyo, JP;

Inventors:

Yoshihiko Norimine, Tsukuba, JP;

Kunitoshi Takeda, Tsukuba, JP;

Koji Hagiwara, Tsukuba, JP;

Yuichi Suzuki, Tsukuba, JP;

Yuki Ishihara, Tsukuba, JP;

Nobuaki Sato, Tsukuba, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/54 (2006.01); A01N 43/58 (2006.01); A01N 43/60 (2006.01); A61K 31/505 (2006.01); A61K 31/535 (2006.01); C07D 413/00 (2006.01); C07D 487/00 (2006.01); C07D 471/00 (2006.01); C07D 403/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein Ris a hydrogen atom; Ris an aromatic ring group, etc.; Ris a hydrogen atom, etc; Ris a hydrogen atom; Ris an oxepanyl group, etc.; Ris a hydrogen atom.


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