The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Apr. 30, 2009
Rafi Ahmed, Atlanta, GA (US);
Joseph Miller, Atlanta, GA (US);
Patrick C. Wilson, Chicago, IL (US);
J. Donald Capra, Oklahoma City, OK (US);
Jens Wrammert, Decatur, GA (US);
Rafi Ahmed, Atlanta, GA (US);
Joseph Miller, Atlanta, GA (US);
Patrick C. Wilson, Chicago, IL (US);
J. Donald Capra, Oklahoma City, OK (US);
Jens Wrammert, Decatur, GA (US);
Oklahoma Medical Research Foundation, Oklahoma City, OK (US);
Emory University, Atlanta, GA (US);
Abstract
High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19CD3CD20CD38CD27cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained at a time that the fraction of PBMC expressing antibody reactive to the antigen is at a high level. Sequences encoding heavy and light chain variable domains are prepared in a manner that allow production of molecules with natural heavy and light chain pairing.