The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Nov. 17, 2010
Ruxandra Draghia-akli, Brussels, BE;
Melissa Pope, The Woodlands, TX (US);
Ruxandra Draghia-Akli, Brussels, BE;
Melissa Pope, The Woodlands, TX (US);
VGX Pharmaceuticals, Inc., Blue Bell, PA (US);
Abstract
One aspect of the current invention is an optimized synthetic mammalian expression plasmid with a mutated origin of replication (e.g. 'mut' family of plasmids) comprising a therapeutic element, and a replication element. The therapeutic elements of this plasmid are operatively linked and located in a first operatively-linked arrangement. Additionally, the optimized synthetic mammalian expression plasmid comprises replication elements, wherein the replication elements are operatively linked and located in a second operatively-linked arrangement. The first-operatively-linked arrangement and the second-operatively-linked arrangement comprise a circular structure of the codon optimized synthetic mammalian expression plasmid.