The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Dec. 19, 2008
Ben DE Lange, Munstergeleen, NL;
Anna Maria Cornelia Francisca Castelijns, Spaubeek, NL;
Johannes Gerardus DE Vries, Maastricht, NL;
Andreas Hendrikus Maria DE Vries, Maastricht, NL;
Jeroen Antonius Franciscus Boogers, Maastricht, NL;
Quirinus Bernardus Broxterman, Munstergeleen, NL;
Ben De Lange, Munstergeleen, NL;
Anna Maria Cornelia Francisca Castelijns, Spaubeek, NL;
Johannes Gerardus De Vries, Maastricht, NL;
Andreas Hendrikus Maria De Vries, Maastricht, NL;
Jeroen Antonius Franciscus Boogers, Maastricht, NL;
Quirinus Bernardus Broxterman, Munstergeleen, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with Rbeing a branched Calkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).