The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Apr. 02, 2012
Ming-yu Liu, Hsinchu, TW;
Yuh-shyong Yang, Hsinchu, TW;
Yen-pei LU, Hsinchu, TW;
Chih-heng Lin, Hsinchu, TW;
Ming-Yu Liu, Hsinchu, TW;
Yuh-Shyong Yang, Hsinchu, TW;
Yen-Pei Lu, Hsinchu, TW;
Chih-Heng Lin, Hsinchu, TW;
National Applied Research Laboratories, Taipei, TW;
Abstract
A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle.