The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Jun. 26, 2008
Else Marie Agger, Copenhagen, DK;
Claire Andersen, Bogliasco, IT;
Peter Andersen, Brønshøj, DK;
Gurdyal S. Besra, Solihull, GB;
David E. Minnikin, Keswick, GB;
Else Marie Agger, Copenhagen, DK;
Claire Andersen, Bogliasco, IT;
Peter Andersen, Brønshøj, DK;
Gurdyal S. Besra, Solihull, GB;
David E. Minnikin, Keswick, GB;
Statens Serum Institut, Copenhagen S, DK;
Abstract
Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived fromBCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.