The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Dec. 04, 2002
Jose Enrique Montero Casimiro, Cuidad Habana, CU;
Rolando Perez Rodriguez, Cuidad Habana, CU;
Agustin Bienvenido Lage Davila, Cuidad Habana, CU;
Jose Enrique Montero Casimiro, Cuidad Habana, CU;
Rolando Perez Rodriguez, Cuidad Habana, CU;
Agustin Bienvenido Lage Davila, Cuidad Habana, CU;
Centro de Inmunologia Molecular, Havana, CU;
Abstract
The present invention relates to methods of treatment useful in chronic diseases, by means of the rupture of tolerance to self-antigens and increasing autoimmune response against these antigens. More particularly, the present invention relates to methods useful in the treatment of tumors that are growth dependent on the Epidermal Growth Factor, including non-small cell lung carcinoma. In the present invention a therapeutic combination is revealed that includes the combination of a vaccine against self antigens with a monoclonal antibody against peripheral T cells or a chemotherapeutic drug able to induce a depletion of peripheral T cells. In another one of its aspects the present invention reveals a method of treatment of chronic diseases in which the rupture of the tolerance to self antigens is essential for the control of the disease, this method includes the administration of a immune suppressor agent between two cycles of vaccination against a self antigen, which could be for example the EGF, being this scheme of effective treatment for the reduction of tumors whose growth depends on EGF.