The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2013
Filed:
Jul. 17, 2008
Simon Goodman, Griesheim, DE;
Diane Hahn, Seeheim-Jugenheim, DE;
Francesc Mitjans, Igualada, ES;
Jaume Adan, Mataro, ES;
Kin-ming Lo, Lexington, MA (US);
Simon Goodman, Griesheim, DE;
Diane Hahn, Seeheim-Jugenheim, DE;
Francesc Mitjans, Igualada, ES;
Jaume Adan, Mataro, ES;
Kin-Ming Lo, Lexington, MA (US);
Merck Patent GmbH, Darmstadt, DE;
Abstract
The invention relates to engineered antibodies which specifically bind to integrin receptors, especially the alpha V integrin receptor subunit. The antibodies comprise the antigen binding sites (CDRs) of a known mouse anti-integrin antibody, as well as hybrid light chain variable sequences, mutated heavy chain variable sequences (Frs) and modified heavy chain constant sequences. The novel antibodies have improved immunogenic and expression properties and elicit excellent anti-angiogenic as well as anti-tumor activities in humans in monotherapy but also and above all in combination with other angiogenesis and tumor inhibiting agents.