The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Apr. 20, 2011
Zijun Liu, Suzhou, CN;
Sanhui Lin, Suzhou, CN;
Wenge LI, Plainsboro, NJ (US);
Jingyang Zhu, Monmouth Junction, NJ (US);
Xinjun Liu, Suzhou, CN;
Xiaojuan Zhang, Suzhou, CN;
Hui LU, Suzhou, CN;
Fei Xiong, Suzhou, CN;
Zhongwei Tian, Suzhou, CN;
Zijun Liu, Suzhou, CN;
Sanhui Lin, Suzhou, CN;
Wenge Li, Plainsboro, NJ (US);
Jingyang Zhu, Monmouth Junction, NJ (US);
Xinjun Liu, Suzhou, CN;
Xiaojuan Zhang, Suzhou, CN;
Hui Lu, Suzhou, CN;
Fei Xiong, Suzhou, CN;
Zhongwei Tian, Suzhou, CN;
Chiral Quest, Inc., Monmouth Junction, NJ (US);
Abstract
A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril: