The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Jun. 07, 2011
Jonathan M. Miller, Lindenhurst, IL (US);
Rajeev Gokhale, Helios, SG;
Eric A. Schmitt, Libertyville, IL (US);
Yi Gao, Vernon Hills, IL (US);
Justin Lafountaine, Chicago, IL (US);
Lloyd Dias, Gurnee, IL (US);
Jonathan M. Miller, Lindenhurst, IL (US);
Rajeev Gokhale, Helios, SG;
Eric A. Schmitt, Libertyville, IL (US);
Yi Gao, Vernon Hills, IL (US);
Justin Lafountaine, Chicago, IL (US);
Lloyd Dias, Gurnee, IL (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N'-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer.