The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
May. 03, 2011
Applicants:
Andrea Castellin, Mestrino, IT;
Michele Maggini, Selvazzano Dentro, IT;
Paola Donnola, Padua, IT;
Inventors:
Assignee:
F.I.S. Fabbrica Italiana Sintetici S.p.A., Alte di Montecchio Maggiore, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention refers to a process for the preparation of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular Midazolam, through an efficient and selective decarboxylation reaction of the derivative compound of the 5-aminomethyl-1-phenyl-1H-imidazole-4-carboxylic acid of formula (II) avoiding the formation of the 6H-imidazo[1,5-a][1,4]benzodiazepines by-products and the ensuing process for the isomerization of a 4H-imidazo[1,5-a][1,4]benzodiazepine product.