The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Apr. 07, 2009
Michael John Scott Saunders, Brussels, BE;
Johannes Joseph Wilhelmus DE Haard, Oudelande, NL;
Edward Dolk, Utrecht, NL;
Renee DE Bruin, Utrecht, NL;
Peter Vanlandschoot, Bellem, BE;
Michael John Scott Saunders, Brussels, BE;
Johannes Joseph Wilhelmus De Haard, Oudelande, NL;
Edward Dolk, Utrecht, NL;
Renee De Bruin, Utrecht, NL;
Peter Vanlandschoot, Bellem, BE;
Ablynx N.V., Zwijnaarde, BE;
Abstract
The present invention relates to amino acid sequences (also referred to herein as 'single variable domain(s) of the invention'. 'Nanobody™ of the invention' or “Nanobodies™ of the invention”, ilpolypeptide(s) of the invention”) that are directed against (as defined herein) members of the Notch signalling pathway such as the four mammalian members of the Notch Receptors (Notch-1, Notch-2, Notch-3, Notch-4, hereinafter also “Notch Receptors”) and the five mammalian members of the Notch Ligands (the Delta-like family with “DLL1”, “DLL3”, “DLL4” wherein “DLL” stands for Delta-like ligand; the Jagged family with “Jagged-1”, “Jagged-2”, hereinafter also “Notch Ligands”), as well as to constructs that comprise or essentially consist of one or more such single variable domain(s) (also referred to herein as “construct of the invention” and “constructs of the invention”, “Nanobody™ of the invention” or “Nanobodies™ of the invention”, respectively). In particular, this invention relates to Notch pathway interfering single variable domains down- or up-regulating Notch signaling (also referred to herein “Notch-antagonists” or “Notch-agonists”).