The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Mar. 30, 2010
Christine Klinguer-hamour, Groisy, FR;
Alexandra Jouhanneaud, Bonneville, FR;
Véronique Grenier-caussanel, Saint Martin du Fresne, FR;
Christine Klinguer-Hamour, Groisy, FR;
Alexandra Jouhanneaud, Bonneville, FR;
Véronique Grenier-Caussanel, Saint Martin du Fresne, FR;
Pierre Fabre Medicament, Boulogne Billancourt, FR;
Abstract
The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. More particularly, the present invention relates to the 414H5 and 515H7 antibodies, specific to the CXCR4 protein, as well as their use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.