The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Feb. 09, 2011
Zhujun Yao, Shanghai, CN;
Bing Sun, Shanghai, CN;
Yangtong Lou, Shanghai, CN;
Zhenyu Yang, Shanghai, CN;
Aizhong Chen, Shanghai, CN;
Zhao MA, Shanghai, CN;
Zhujun Yao, Shanghai, CN;
Bing Sun, Shanghai, CN;
Yangtong Lou, Shanghai, CN;
Zhenyu Yang, Shanghai, CN;
Aizhong Chen, Shanghai, CN;
Zhao Ma, Shanghai, CN;
Abstract
The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).