The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2013
Filed:
Jun. 05, 2008
Adrian L. Smith, Simi Valley, CA (US);
Elizabeth M. Doherty, Thousand Oaks, CA (US);
Qi Huang, Moorpark, CA (US);
Gang Liu, Oak Park, CA (US);
Adrian L. Smith, Simi Valley, CA (US);
Elizabeth M. Doherty, Thousand Oaks, CA (US);
Qi Huang, Moorpark, CA (US);
Gang Liu, Oak Park, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A, A, A, A, A, A, A, A, A, bond B, X, rings Zand Z, Rand Rare defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.